McCrary's work in the late 1990s suggested that superheroes influence children's development of moral values. Similarly, Bauer and Dettore advocated adults' and educators' monitoring of children's superhero play to help children foster cooperation and conflict resolution skills. The purpose of this study was to explore the relationship between children's attitudes toward themselves and their attitudes towards superheroes. Forty‐two fourth‐grade children (aged 9–11) from a school in Massachusetts completed a questionnaire. Results indicated that participants generally rated themselves and their superhero as (...) being high on prosocial behaviour. Findings suggest that there may be a relationship between how children feel about themselves and how they feel about superheroes. (shrink)

Drawing on contemporary agency theory and the phenomenological-existential tradition, this paper uses Mr. Stevens, the narrator-butler of Kazuo Ishiguro’s The Remains of the Day, to examine the interplay and potential tensions between different aspects (and thus different standards) of human agency. Highlighting the problem of mission creep described by John Martin Fischer, in which a notion expands beyond the original purpose, I use Stevens’s thoughts on dignity to outline three different ways actions can (or can fail to) trace back (...) to agents—autonomy as self-control, authenticity as sincerity, and authenticity as ownership. I then propose that the way Stevens embraces and acts consistently within his subservient professional role (autonomy as self-control) weakens his ability to take responsibility for his life in the sense required by authenticity as ownership. Because the self-responsibility of authenticity requires normative flexibility (the ability to revise and reshape one’s commitments and values), when normatively inflexible agents act in self-controlled ways according to their roles or welfare standards, they may limit their ability to take responsibility for their lives. In addition to illuminating debates about whether robust human agency is compatible with subservience, the normative flexibility involved in authenticity has implications for human agency more broadly. (shrink)

Zuko’s plight illuminates the process of aspiration, including common challenges to the aspirant. As Agnes Callard understands it, aspiration typically involves a “deep change in how one sees and feels and thinks.” And this deep change is often intertwined with a change in what contemporary philosopher Christine Korsgaard calls practical identity, a “description under which you value yourself, . . . under which you find your life to be worth living and your actions to be worth undertaking.” But as Zuko (...) shows, practical identities are complex, sometimes unwieldy, and changes in explicit self-conceptions can take work, time, and perhaps some luck to bring about the deep change one aspires to. Even after he explicitly disavows his past actions, Zuko finds himself reverting to past behaviors, doing things that (on some level) he wishes he would not. These actions frustrate him— “Why am I so bad at being good?”— but they are not mere lapses in judgment. They come naturally and express an identity that Zuko had long embraced and cultivated but is now trying to leave behind. The arc of Zuko’s transformation illustrates the interplay between two dimensions of practical identity. On the one hand, as Korsgaard’s account emphasizes, our explicit self-conceptions and values matter. They guide our actions and shape how we see the world. But Zuko’s struggles suggest that such self-conceptions and aspirations are only part of the story. According to Martin Heidegger’s notion of being-in-the-world, our practical identity depends more on our existential engagement with the world than on our explicit self-conceptions. And these different dimensions of practical identity do not always align. As William Blattner writes, “Some of the most challenging conflicts in our lives arise when who we are existentially engaged in being stands in tension with who we think of ourselves as being.” Zuko is frustrated because, despite consciously trying to change, his being-in-the-world conflicts with his Korsgaardian practical identity. His world is still shaped (residually) by an identity he wants to shed. The way Zuko’s world and actions continue to be shaped by an identity he is trying to leave behind highlights a key difficulty of transformation. Zuko’s desire to prove his worth to his father and his rage have so thoroughly permeated his being-in-the-world that they are second nature. They shape his orientation toward the world and fuel his firebending. For better and worse, his spontaneous actions do not always fall in step with his conscious commitments. The same skills and dispositions Zuko previously cultivated as central to his identity now lead to unwanted actions and keep him from aspired-to actions. To become good in the way he wants, Zuko must not only cultivate the dispositions that will allow his aspired-to identity to become part and parcel of his being-in-the-world, but he must clear out or modify the residual influence of his past identity and related dispositions and values. -/- . (shrink)

Disavowals such as "That's not who I am" are one way to distance ourselves from unsavory actions in order to try to mitigate our responsibility for them. Although such disclaimers can be what Harry Frankfurt calls "shabbily insincere devices for obtaining unmerited indulgence," they can also be a way to renew our commitments to new values as part of the processes of aspiration and moral improvement. What, then, separates backsliding aspirants from those in denial who seek unmerited indulgence? Drawing on (...) Christine Korsgaard, on the one hand, and Heidegger and Merleau-Ponty, on the other, I propose a two-dimensional account of practical identity that makes sense of a certain kind of self-ignorance and helps us distinguish the aspirant from the superficially similar cases of denial and resignation. A key factor is how one responds to what I call residual practical identities. (shrink)

This study examines the outcomes of a four-year faculty learning community (FLC) that aimed to transform departmental ethics curriculum by supporting Earth Sciences faculty members as they ethically inquired into their teaching of ethics and refined existing courses in alignment with an Integrated Community-Engaged Learning and Ethical Reflection (ICELER) framework. We present ethnographic case studies that unpack processes through which three faculty members transformed undergraduate courses. We assembled case studies by triangulating interview data, course artifacts, and faculty reflections. We examine (...) how faculty (1) built awareness around teaching ethics, (2) took responsibility for and made judgments about teaching ethics, (3) experimented by designing and implementing ICELER-inspired courses, and (4) interrogated the outcomes of their ethics teaching, utilizing findings to enhance awareness and revise courses. The paper closes by introducing a model detailing how instructors inquire into ethics teaching and how model components might inspire future educational practice and research. (shrink)

Because anticipated and retrospective regret play important roles in practical deliberation and motivation, better understanding them can illuminate the contours of human agency. However, the possibility of self-ignorance and the fact that we change over time can make regret—especially anticipatory regret—not only a poor predictor of where the agent will be in the future but also an unreliable indicator of where the agent stands. Granting these, this paper examines the way in which prospective and, particularly, retrospective regret can nevertheless yield (...) important insight into the sorts of creatures we are, both generally and individually. The experience of retrospective regret can show a person she values something in a way she did not know or that she is (or was) a different person than she had thought, insights which can factor into forward-looking, or prospective, deliberation. Such instances of revelatory regret reveal something to the agent about herself as agent. I examine two cases of agential self-ignorance. In the first, the experience of regret reveals what the agent values, not only to others but even to the agent himself. In the second, the agent anticipates experiencing regret for an action but does not experience the regret, suggesting that the agent did not value the rejected alternative in the way she thought. Anticipatory regret is forward-looking and can play an important role in practical deliberation. But insofar as anticipatory regret flows from one’s imperfect judgment and prospection about oneself, retrospective regret can be an important corrective in helping the agent understand her own standpoint. (shrink)

In Aspiration, Agnes Callard examines the phenomenon of aspiration, the process by which one acquires values and becomes a certain kind of person. Aspiring to become a certain type of person involves more than wanting to act in certain ways. We want to come to see the world in a certain way and to develop the dispositions, attributes, and skills that allow us to seamlessly and effectively respond to situations. The skilled athlete or musician, for example, has developed the muscle (...) memory and the perceptual equivalent to naturally see what a situation requires and to respond well, whether playing a Rachmaninoff concerto or returning a tennis volley. -/- I use Merleau-Ponty’s Phenomenology of Perception to flesh out the process of becoming, through which aspired-to values, skills, and characteristics become part of one’s embodied being-in-the-world. Although some rightly focus on Merleau-Ponty’s efforts to avoid over-intellectualizing skillful action, without appreciating his distinction between habitual actions and human (or personal) acts, we overlook an important aspect of robust human agency—the way “a human act becomes dormant and is continued absent-mindedly as a reflex” (90). Merleau-Ponty’s account of habit and its relation to personal acts offers a rich and phenomenologically sensitive picture of aspiration. (shrink)

Hubert Dreyfus’s work in the phenomenology of agency is distinctive for the privileged and central position he gives to our ability to navigate the everyday world. Drawing on the existential-phenomenological tradition—particularly the work of Heidegger and Merleau-Ponty—Dreyfus characterizes skillful embodied engagement with the world (skillful coping) as the paradigmatic instance of human intelligence and agency. He uses the notion of skillful coping to push against the emphasis on deliberation he finds in the traditional view of human agency. One of Dreyfus’s (...) central claims is that the complex understanding involved in skillful coping need not be highly reflective. -/- Dreyfus connects the ability to respond to the particular significances of a concrete situation with typically existential concerns, such as authenticity. The way Dreyfus connects skillful coping with authenticity exemplifies his syncretic approach in which he synthesizes and, arguably, extends the work of thinkers such as Heidegger and Merleau-Ponty. -/- The concluding section examines one worry about Dreyfus’s characterization of expertise within the skillful coping paradigm. Specifically, does Dreyfus’s rejection of the tradition’s emphasis on deliberation lead him to excessively minimize the role of deliberation as one develops and expands expertise? My suggestion is that there is space for such deliberate learning and skill development for experts within the framework Dreyfus proposes. To flesh out the place of deliberate learning, I draw on both Dreyfus and Merleau-Ponty to suggest how intentionally (and deliberately) trying to live in a certain way is not at odds with but is ultimately crucial for the expertise of absorbed, fluid, and skillful coping in a practical world. (shrink)

In The Sickness unto Death, Kierkegaard describes selfhood as an achievement, specifically claiming that the self’s task ‘is to become itself’ (SUD, 29/SKS 11, 143). But how can one can become who or what one already is, and what sort of achievement is it? This chapter draws on the work of Christine Korsgaard, another philosopher who sees selfhood as an achievement, using her notion of practical identity to explore Kierkegaard’s accounts of the structure of the self and of selfhood as (...) achievement. Kierkegaard’s treatment of selfhood—as aspirational and, if undertaken well, appropriately grounded in one’s facticity (i.e. the concrete facts of one’s situation)—suggests how consciously endorsed identities can guide (or fail to guide) our agency. Having a practical identity involves striving to inhabit adopted roles by aligning our actions with relevant normative demands, but also sometimes embracing and consciously adopting identities already tacitly guiding our engagement with the world. This framework also suggests several ways we can be alienated from desires, actions, or, more generally, our selves. Putting Kierkegaard in conversation with contemporary agency theory, this chapter has two guiding lines of inquiry. First, what does it mean to achieve selfhood and how can the notion of practical identity illuminate or be illuminated by this question? Second, how can this analysis clarify the experience of not being oneself, whether resulting from self-deception, self-ignorance, or the potentially frustrating gap between who one is and who one wants to be? (shrink)

Influential interpretations of Heidegger’s Origin of the Work of Art focus on the view that great art is massive and communal—typically structures like temples and cathedrals. This approach, however, faces two interpretive problems. First, what are we to do with artworks in the essay that clearly are not monumental or communal, such as van Gogh’s Shoes? Second, how should we understand our experience of works such as the Greek temple, which once were but are no longer central in this way? (...) Heidegger himself says that great art of the past becomes either a relic of the past or a mere object of aesthetic experience, but his description of his own experience with a Greek temple seems to contradict this. To understand Heidegger’s views on art—including his explicit claims about the limited vitality of great art of the past and his unintentional case for the continued power of great art of the past—it is crucial to distinguish, first, between Heidegger’s notions of world and worldhood, and, second, between two senses of what makes art great—world disclosure and world gathering. Doing so allows us to make better sense both of the essay as a whole and the potential continued vitality of great art of the past. (shrink)

Evaluating other people's moral character is a crucial social cognitive task. However, the cognitive processes by which people seek out, prioritize, and integrate multiple pieces of character‐relevant information have not been studied empirically. The first aim of this research was to examine which character traits are considered most important when forming an impression of a person's overall moral character. The second aim was to understand how differing levels of trait expression affect overall character judgments. Four preregistered studies and one supplemental (...) study (total N = 720), using five different measures of importance and sampling undergraduates, online workers, and community members, found that our participants placed the most importance on the traits honest, helpful, compassionate, loyal, and responsible. Also, when integrating the information that they have learned, our participants seemed to engage in a simple averaging process in which all available, relevant information is combined in a linear fashion to form an overall evaluation of moral character. This research provides new insights into the cognitive processes by which evaluations of moral character are formed. (shrink)

May expresses optimism about the source, content, and consequences of moral judgments. However, even if we are optimistic about their source (i.e., reasoning), some pessimism is warranted about their content, and therefore their consequences. Good reasoners can attain moral knowledge, but evidence suggests that most people are not good reasoners, which implies that most people do not attain moral knowledge.

Recent theorizing about the cognitive underpinnings of dilemmatic moral judgment has equated slow, deliberative thinking with the utilitarian disposition and fast, automatic thinking with the deontological disposition. However, evidence for the reflective utilitarian hypothesis—the hypothesized link between utilitarian judgment and individual differences in the capacity for rational reflection has been inconsistent and difficult to interpret in light of several design flaws. In two studies aimed at addressing some of the flaws, we found robust evidence for a reflective minimalist hypothesis—high CRT (...) performers’ tendency to regard utility-optimizing acts as largely a matter of personal prerogative, permissible both to perform and to leave undone. This relationship between CRT and the “minimalist” orientation remained intact after controlling for age, sex, trait affect, social desirability, and educational attainment. No significant association was found between CRT and the strict utilitarian response pattern or CRT and the strict deontological response pattern, nor did we find any significant association between CRT and willingness to act in the utility-optimizing manner. However, we found an inverse association between empathic concern and a willingness to act in the utility-optimizing manner, but there was no comparable association between empathic concern and the deontological judgment pattern. Theoretical, methodological, and normative implications of the findings are discussed. (shrink)

Theories that view emotions as being related in some way to moral judgments suggest that condemning moral emotions should, at a minimum, be understood by laypeople to coincide with judgments of mor...

Psychiatry is rapidly adopting digital phenotyping and artificial intelligence/machine learning tools to study mental illness based on tracking participants’ locations, online activity, phone and text message usage, heart rate, sleep, physical activity, and more. Existing ethical frameworks for return of individual research results (IRRs) are inadequate to guide researchers for when, if, and how to return this unprecedented number of potentially sensitive results about each participant’s real-world behavior. To address this gap, we convened an interdisciplinary expert working group, supported by (...) a National Institute of Mental Health grant. Building on established guidelines and the emerging norm of returning results in participant-centered research, we present a novel framework specific to the ethical, legal, and social implications of returning IRRs in digital phenotyping research. Our framework offers researchers, clinicians, and Institutional Review Boards (IRBs) urgently needed guidance, and the principles developed here in the context of psychiatry will be readily adaptable to other therapeutic areas. (shrink)

That this is one of the most distinguished books in the excellent Bradford Books cognitive science/philosophy series is suggested by the March 1983 issue of Behavioral and Brain Sciences, in which we find a precis of the book, some twenty commentaries, and Dretske's replies. Physicalists and anti-physicalists in psychology have both stressed the importance of "top-down" strategies and have debated, prospectively, about the likelihood that we eventually will have suitable reductions, or explanatory instantiations, of psychological generations in neurophysiological terms. Dretske (...) takes the more straightforward approach, starting with an avowedly physical notion of information and then trying to show how one can make, building on this foundation, a reasonable construal of knowledge, perception, and belief. Dretske starts with the following information-theoretic specification of a signal's information content: a signal r carries the information that s is F = the conditional probability of s's being F, given r, is l. Thus, to use Dretske's humble example, "My gas gauge carries the information that I still have some gas left, if and only if the conditional probability of my having some gas left, given the reading of the gauge, is l." The parenthetical clause makes the causal character of this analysis clear: the state of the source is related by physical laws to the occurrence of the signal--the gas in the tank causes the gauge reading. Insisting on the conditional probability of l has the advantage of preserving the properties of certainty, transitivity, and addition that we associate with knowledge. If the gas gauge does carry the information that my tank has gas, then my tank must have gas. If my statement that my gauge indicates gas carries the information that it does so indicate, then information flows intact from signal to signal. And finally, if the signal carries the information that s is F, and also carries the information that s is G, then it carries, at the same level of probability assigned each, the information that s is F and G. Now we can, eventually, say that K knows that s is F = K's belief that s is F is caused by the information that s is F. The "eventually" part is important, for what is most instructive and provoking about this book is the way in which Dretske lays out the steps in constructing viable construals of knowledge, perception, and belief out of the root notion of information.--Justin Leiber, The University of Houston. (shrink)

Clinical Ethics, Ahead of Print. This paper is a response to a recent BMJ Blog: ‘The duty to treat: where do the limits lie?’ Members of the Surrey Heartlands Integrated Care Service Clinical Ethics Group reflected on arguments in the Blog in relation to resuscitation during the COVID-19 pandemic.Clinicians have had to contend with ever-changing and conflicting guidance from the Resuscitation Council UK and Public Health England regarding personal protective equipment requirements in resuscitation situations. St John Ambulance had different guidance (...) for first responders.The situation regarding resuscitation led the CEG to consider ethical aspects of health care professionals’ responses to the need for resuscitation during COVID-19. Members agreed that professionals should, ideally, have the level of PPE required for an aerosol generating procedure. However, there was no consensus regarding professionals’ duty to care when this is not available. On the one hand, it was agreed that the casualty/patient’s interests regarding resuscitation should be prioritised due to professionals’ contract with the public and professional privilege. On the other hand, risk thresholds were considered relevant to individual decision-making and professionals’ duty to care. All agreed that decision-making should not be influenced by rewards or reprimands. It was agreed also that decisions to resuscitate should not be considered as moral heroism or supererogatory - regardless of PPE availability - but rather as ‘minimally decent’. We agreed that it may be acceptable for professionals, with good reasons, to opt out of resuscitation attempts and these should be reflected on and discussed before the event. (shrink)

John Martin Fischer has argued that Molinism does not constitute a response to the argument that divine foreknowledge is incompatible with human freedom. I argue that T. Ryan Byerly’s recent work on the mechanics of foreknowledge sheds light on this issue. It shows that Fischer’s claim is ambiguous, and that it may turn out to be false on at least one reading, but only if the Molinist can explain how God knows true counterfactuals of freedom.

Reduced Environmental Stimulation Therapy (REST) alters the balance of sensory input to the nervous system by systematically attenuating sensory signals from visual, auditory, thermal, tactile, vestibular, and proprioceptive channels. Previous research from our group has shown that REST via floatation acutely reduces anxiety and blood pressure while simultaneously heightening interoceptive awareness in clinically anxious populations. Anorexia nervosa (AN) is an eating disorder characterized by elevated anxiety, distorted body representation, and abnormal interoception, raising the question of whether REST might positively impact (...) these symptoms. However, this approach has never been studied in eating disorders and it is unknown whether exposure to REST might worsen AN symptoms. To examine these possibilities we conducted an open-label study to investigate the safety and tolerability of REST in AN. We also explored the impact of REST on affective symptoms, body image disturbance, and interoception. Twenty-one partially weight-restored AN outpatients completed a protocol involving four sequential sessions of REST: reclining in a zero-gravity chair, floating in an open pool, and two sessions of floating in an enclosed pool. All sessions were 90 minutes, approximately one week apart. We measured orthostatic blood pressure before and immediately after each session (primary outcome), in addition to collecting blood pressure readings every 10 minutes during the session using a wireless waterproof system as a secondary outcome measure. Each participant's affective state, awareness of interoceptive sensations, and body image was assessed before and after every session (exploratory outcomes). There was no evidence of orthostatic hypotension following floating, and no adverse events (primary outcome). Secondary analyses revealed that REST induced statistically significant reductions in blood pressure, anxiety and negative affect, heightened awareness of cardiorespiratory but not gastrointestinal sensations, and reduced body image dissatisfaction. The findings from this initial trial suggest that individuals with AN can safely tolerate the physical effects of REST via floatation. Future randomized controlled trials will need to investigate whether these initial observations of improved anxiety, interoception, and body image disturbance can be effectively extended to acutely ill AN populations. (shrink)

Despite thermodynamic, bioenergetic and phylogenetic failings, the 81‐year‐old concept of primordial soup remains central to mainstream thinking on the origin of life. But soup is homogeneous in pH and redox potential, and so has no capacity for energy coupling by chemiosmosis. Thermodynamic constraints make chemiosmosis strictly necessary for carbon and energy metabolism in all free‐living chemotrophs, and presumably the first free‐living cells too. Proton gradients form naturally at alkaline hydrothermal vents and are viewed as central to the origin of life. (...) Here we consider how the earliest cells might have harnessed a geochemically created proton‐motive force and then learned to make their own, a transition that was necessary for their escape from the vents. Synthesis of ATP by chemiosmosis today involves generation of an ion gradient by means of vectorial electron transfer from a donor to an acceptor. We argue that the first donor was hydrogen and the first acceptor CO2. (shrink)

In this book, Justin N. Bonanno builds off of the recent philosophical work on Walker Percy’s writings. While it is valuable to appreciate Percy as a novelist, Bonanno approaches Percy from the perspective of Continental philosophy and the rhetorical tradition. Unpacking the works of several key authors that influenced Percy (e.g. Sartre and Heidegger), Bonanno offers a fresh philosophical account of Percy's ideas concerning the relationship between symbols and existence. In particular, he focuses on how Percy’s ideas emerge from (...) the thought of Ernst Cassirer, Susanne Langer, Jacques Maritain, Jean-Paul Sartre, Gabriel Marcel, Martin Heidegger, Viktor Shklovsky, Søren Kierkegaard, and St. Thomas Aquinas. (shrink)

Pretendemos neste trabalho sustentar a ideia de que, seguindo um percurso que vai de Sein und Zeit aos textos mais tardios, a compreensão do pensar, especialmente tendo em conta a íntima relação desta compreensão com o conceito de existência, esteve caracterizada pela concepção de finitude. Assim, segundo esta hipótese, o pensamento da história do ser teria como meta revelar ao mesmo tempo o retraimento do ser que se opera por um pensar – chamemo-lo de “expropriador” – e a necessidade de (...) se inaugurar um novo pensar, que é o que estaria em jogo na viragem. Intuídos já em Sein und Zeit morte e finitude, firmar-se-iam como conceitos nucleares para a compreensão da importância, do alcance e da posteridade da filosofia heideggeriana. (shrink)

BackgroundIndustry funding and author conflicts of interest (COI) have been consistently shown to introduce bias into agenda-setting and results-reporting in biomedical research. Accordingly, maintaining public trust, diminishing patient harm, and securing the integrity of the biomedical research enterprise are critical policy priorities. In this context, a coordinated and methodical research effort is required to effectively identify which policy interventions are most likely to mitigate against the risks of funding bias. Subsequently this scoping review aims to identify and synthesize the available (...) research on policy mechanisms designed to address funding bias and COI in biomedical research.MethodsWe searched PubMed for peer-reviewed, empirical analyses of policy mechanisms designed to address industry sponsorship of research studies, author industry affiliation, and author COI at any stage of the biomedical research process and published between January 2009 and 28 August 2023. The review identified literature conducting five primary analysis types: (1) surveys of COI policies, (2) disclosure compliance analyses, (3) disclosure concordance analyses, (4) COI policy effects analyses, and (5) studies of policy perceptions and contexts. Most available research is devoted to evaluating the prevalence, nature, and effects of author COI disclosure policies.ResultsSix thousand three hundreds eighty five articles were screened, and 81 studies were included. Studies were conducted in 11 geographic regions, with studies of international scope being the most common. Most available research is devoted to evaluating the prevalence, nature, and effects of author COI disclosure policies. This evidence demonstrates that while disclosure policies are pervasive, those policies are not consistently designed, implemented, or enforced. The available evidence also indicates that COI disclosure policies are not particularly effective in mitigating risk of bias or subsequent negative externalities.ConclusionsThe results of this review indicate that the COI policy landscape could benefit from a significant shift in the research agenda. The available literature predominantly focuses on a single policy intervention–author disclosure requirements. As a result, new lines of research are needed to establish a more robust evidence-based policy landscape. There is a particular need for implementation research, greater attention to the structural conditions that create COI, and evaluation of policy mechanisms other than disclosure. (shrink)

Topics covered include queering the domestic by examining the diverse functionings of "home" for past and present LGBTQ+ and other marginalized groups; housing precarity and homelessness; LGBTQ+ social movements; kinship and caretaking; LGBTQ+ representation in literature and film; and ethnographies of everyday life. Contributors: Rasel Ahmed, Miguel Avalos, Darius Bost, Zhen Cheng, Ariel Dela Cruz, René Esparza, Jules Gill-Peterson, Gayatri Gopinath, Lauren Jae Gutterman, Joseph Henry, Efadul Huq, Holly Jackson, Jina B. Kim, Martin F. Manalansan IV, Sara Matthiesen, Nivati (...) Misra-Shenoy, Richard Mora, Shoniqua Roach, Cody St. Clair, Maggie Schreiner, Gee Imaan Semmalar, Virginia Thomas, Stephen Vider, Hentyle Yapp. (shrink)

The American Journal of Bioethics, Volume 12, Issue 10, Page 18-20, October 2012.

Introduction Financial conflicts of interest (fCOI) present well documented risks to the integrity of biomedical research. However, few studies differentiate among fCOI types in their analyses, and those that do tend to use preexisting taxonomies for fCOI identification. Research on fCOI would benefit from an empirically-derived taxonomy of self-reported fCOI and data on fCOI type and payor prevalence.Methods We conducted a content analysis of 6,165 individual self-reported relationships from COI statements distributed across 378 articles indexed with PubMed. Two coders used (...) an iterative coding process to identify and classify individual fCOI types and payors. Inter-rater reliability was κ = 0.935 for fCOI type and κ = 0.884 for payor identification.Results Our analysis identified 21 fCOI types, 9 of which occurred at prevalences greater than 1%. These included research funding (24.8%), speaking fees (20.8%), consulting fees (18.8%), advisory relationships (11%), industry employment (7.6%), unspecified fees (4.8%), travel fees (3.2%), stock holdings (3.1%), and patent ownership (1%). Reported fCOI were held with 1,077 unique payors, 22 of which were present in more than 1% of financial relationships. The ten most common payors included Pfizer (4%), Novartis (3.9%), MSD (3.8%), Bristol Myers Squibb (3.2%), AstraZeneca (3.1%), GSK (3%), Boehringer Ingelheim (2.9%), Roche (2.8%), Eli LIlly (2.5%), and AbbVie (2.4%).Conclusions These results provide novel multi-domain prevalence data on self-reported fCOI and payors in biomedical research. As such, they have the potential to catalyze future research that can assess the differential effects of various types of fCOI. Specifically, the data suggest that comparative analyses of the effects of different fCOI types are needed and that special attention should be paid to the diversity of payor types for research relationships. (shrink)

The assessment of decision-making capacity in patients with brain injuries presents a range of clinical and legal challenges. Existing guidance on the conduct of such assessments is often generic; guidance specific to patients with brain injury is sparse and coarse-grained. We report on an interview-based study of decision-making capacity in patients suffering from acquired brain injury and organic personality disorder. We identify challenges associated with the assessment of DMC in this patient population, review three bodies of relevant research from cognitive (...) neuropsychology and neurophysiology, and draw on phenomenological analysis to identify three distinct abilities that play a role in decision-making, but which can be compromised in patients with organic personality disorder. We address the challenge of translating clinical findings into legally attestable results. (shrink)

Este artigo busca apresentar as fenomenologias de Husserl e de Heidegger não como dois caminhos isolados na construção do que ulteriormente representou a tradição fenomenológica, mas, ao contrário, identificando pontos de intersecção entre estes dois autores. Para isso recorre ao texto Mein Weg in die Phänomenologie, de Heidegger, publicado em 1963, no qual o já septuagenário filósofo recorre ao seu itinerário pessoal junto à fenomenologia e ao quanto a obra e, posteriormente, a figura de Husserl se mostrariam marcantes na elaboração (...) de seu pensamento – desde suas iniciais intuições como estudante de teologia, passando pelos primeiros anos como professor universitário e culminando na publicação de Sein und Zeit. O reconhecimento deste itinerário exige, porquanto, que a obra de Heidegger seja enxergada em sua relação com a fenomenologia husserliana, donde não apenas recebera o método necessário para a instauração de uma ontologia fundamental, mas a radicalidade inerente à própria atividade filosofante, isto é, o direcionamento às coisas mesmas e, por ele, à essência do pensamento, à coisa do pensar. (shrink)

Despite thermodynamic, bioenergetic and phylogenetic failings, the 81‐year‐old concept of primordial soup remains central to mainstream thinking on the origin of life. But soup is homogeneous in pH and redox potential, and so has no capacity for energy coupling by chemiosmosis. Thermodynamic constraints make chemiosmosis strictly necessary for carbon and energy metabolism in all free‐living chemotrophs, and presumably the first free‐living cells too. Proton gradients form naturally at alkaline hydrothermal vents and are viewed as central to the origin of life. (...) Here we consider how the earliest cells might have harnessed a geochemically created proton‐motive force and then learned to make their own, a transition that was necessary for their escape from the vents. Synthesis of ATP by chemiosmosis today involves generation of an ion gradient by means of vectorial electron transfer from a donor to an acceptor. We argue that the first donor was hydrogen and the first acceptor CO2. (shrink)

We study the quantifier complexity and the relative strength of some fragments of arithmetic axiomatized by induction and minimization schemes for Δn+1 formulas.

Members of the legal, medical and accounting professions are guided in their professional behavior by their respective codes of ethics. These codes of ethics are not static. They are ever evolving, responding to forces that are exogenous and endogenous to the professions. Specifically, changes in the ethical codes are often due to economic and social events, governmental influence, and growth and change within the professions. This paper presents an historical analysis of the major events leading to changes in the legal, (...) medical and accounting codes of ethics. (shrink)

Moral luck is a puzzling aspect of our psychology: Why do we punish outcomes that were not intended (i.e. accidents)? Prevailing psychological accounts of moral luck characterize it as an accident or error, stemming either from a re‐evaluation of the agent's mental state or from negative affect aroused by the bad outcome itself. While these models have strong evidence in their favor, neither can account for the unique influence of accidental outcomes on punishment judgments, compared with other categories of moral (...) judgment. Why might punishment be particularly sensitive to moral luck? We suggest that such sensitivity is easily understood from the broader perspective of punishment's ultimate adaptive goal: Changing others’ behavior by exploiting their capacity to learn. This pedagogical perspective accounts for the exceptional influence of outcomes on punitive sentiments and makes predictions for additional moderators of punishment. We review evidence supporting the pedagogical hypothesis of punishment and discuss fruitful directions for future research. (shrink)

What is the rational response to a scientific disagreement? Many epistemologists argue that disagreement with an epistemic peer should generally lead to conciliation by lowering confidence in the disputed belief or even suspending judgment altogether. Although this conciliatory approach is widely regarded as a norm of individual rationality, its value in the context of collective scientific inquiry is less clear. Some have even raised concerns that conciliating in scientific disagreements may slow progress or reduce the efficiency of inquiry. In this (...) paper, we introduce a novel agent-based model that captures key aspects of scientific disagreement by incorporating both epistemic norms, which govern belief revision, and zetetic norms, which guide how scientists pursue inquiry. Our results indicate that the effects of conciliating in the face of disagreement---whether detrimental or beneficial---depend on the zetetic norms that scientists follow. When they focus on exploiting the hypothesis that they believe is most likely to succeed, remaining steadfast is more effective. However, with exploratory scientists, conciliation does not negatively affect group performance. These findings highlight the critical role of zetetic norms in determining the rational response to disagreement in scientific practice. (shrink)